Efficacy and development prospect of phenylethyl Resorcinol

Phenylethyl resorcinol is a cosmetic raw material with the effect of inhibiting melanin and whitening. It was first developed by German researchers. It was selected after chemical transformation of the natural whitening ingredient silver pine from the pine tower of European red pine.

The chemical name of phenylethyl resorcinol is 4 - (1-phenylethyl) - 1,3-resorcinol, also known as symwhite 377, abbreviated as 377. The product has a molecular weight of 214.26, a melting point of 75 ℃ - 79 ℃, and is a white or beige powder.

Phenylethyl resorcinol is a cosmetic raw material with the effect of inhibiting melanin and whitening. It was first developed by German researchers. It was selected after chemical transformation of the natural whitening ingredient silver pine from the pine tower of European red pine. Phenylethyl resorcinol can effectively inhibit tyrosinase activity and has strong antioxidant capacity. It is better than VE / VC / BHT in antioxidant capacity and is conducive to the regression of melanin. In 2012, the US national food and Drug Administration officially approved 377 as a cosmetic raw material.

Phenylethyl resorcinol has a good effect of inhibiting melanin. At present, there are two main methods of inhibiting melanin production, namely, inhibiting the activity of tyrosinase and controlling the oxidation of dopa. Phenylethyl resorcinol is one of the tyrosinase inhibitors with the highest activity reported. The key factor is that it has a bisphenol structure and can play a competitive role in inhibiting tyrosinase, In recent years, more and more large brand cosmetics have gradually replaced this ingredient.

Phenylethyl resorcinol is often used as a brightener in cosmetics. However, due to the certain irritation of the product on the skin, the dosage of the product is limited. The recommended dosage of the manufacturer is usually 0.1% - 1.0%. The concentration of 377 is limited in China, with the maximum of 0.5%.

Since its research and development, phenylethyl resorcinol has attracted the attention of domestic and foreign researchers. According to the report on the in-depth market research and investment prospect prediction and analysis of the phenylethyl resorcinol industry from 2020 to 2025, the research and development achievements of phenylethyl resorcinol at home and abroad have been increasing in recent years. Such achievements not only include studies that prove that phenylethyl resorcinol has a good effect of inhibiting melanin, but also include some preparation processes, It provides a feasible scheme for the industrialization of phenylethyl resorcinol in China. For example, Liaoning University applied for a patent in 2018: a method suitable for industrial preparation of phenylethyl resorcinol based on HSO SiO solid acid catalyst. This invention introduces a one-step synthesis method of phenylethyl resorcinol under the catalysis of high-efficiency solid acid H2SO4 SiO2. In 2017, Hubei ATEC Biotechnology Co., Ltd. applied for a method to synthesize phenylethyl resorcinol, which is a method to improve the utilization rate of resorcinol and synthesize phenylethyl resorcinol in high yield.

Phenylethyl resorcinol can inhibit the activity of tyrosinase, thereby effectively reducing the production of melanin. When added to cosmetics, it can achieve the effect of whitening and brightening the skin. Moreover, this product has high safety. Through the application of lipid carriers, its stability can be improved. With the development of phenylethyl resorcinol by enterprises and research institutions, the application range of products is becoming wider and wider. In the future, with the advancement of industrial production, phenylethyl resorcinol, as a highly effective whitening agent, will play an increasingly important role, and its products will have a good development prospect.